1 / 1 pts
On an antibody, where do phagocytic cells bind during antibody-mediated opsonization?
  
  
  
  
 
Question 2
1 / 1 pts
Which complement cascade begins with antibodies binding to a pathogen?
  
  
  
  
 
Question 3
1 / 1 pts
After antigen presentation and activation, antibodies are produced and secreted by which cells?
  
  
  
  
 
Question 4
1 / 1 pts
Which of the following correctly describes the process for activated B cells producing different antibody types with the same antigen specificity?
  
  
  
  
 
Question 5
1 / 1 pts
Which of the following statements is true?
  
  
  
  
 
Question 6
1 / 1 pts
It is possible for two different antibodies to recognize the same antigen.
  
  
 
Question 7
2.5 / 2.5 pts

In the next few questions, you are comparing 3 different cell types from one another: NK, T cells and B cells. Please review your lecture notes carefully before submitting!

You can reach out to Dr. Y if you need help identifying which parts you are getting wrong.

NK Cells
Type of immunityinnate
SubtypesN/A
Works onpathogen-infected cells and cancer cells
Function(s)destroy infected host cell
Receptors that this cells "see" to induce function
lack of MHC Class I
Answer 1:
Answer 2:
Answer 3:
Answer 4:
Answer 5:
 
PartialQuestion 8
1.5 / 2.5 pts

Continue working on comparing the different cells, please review your lecture notes carefully before submitting!

If you need help identifying which you are getting wrong, please email Dr. Y.

 

T cells
Type of immunityadaptive
SubtypesTh1, Th2, Tc, Treg, memory
Works onpathogen-infected cells and cancer cells
Function(s)helps to mediate extracellular pathogen targetting and helps to activate other cells
Receptors that this cells "see" to induce function
TCR
Answer 1:
Answer 2:
Answer 3:
Answer 4:
Answer 5:
 
PartialQuestion 9
2 / 2.5 pts

Continue working on comparing the different cells, please review your lecture notes carefully before submitting!

If you need help identifying which you are getting wrong, please email Dr. Y.

 

B cells
Type of immunityadaptive
SubtypesPlasma, memory
Works onextracellular pathogens and antigens
Function(s)helps to mediate extracellular pathogen targetting
Receptors that this cells "see" to induce function
MHC receptors
Answer 1:
Answer 2:
Answer 3:
Answer 4:
Answer 5:
 
Question 10
5 / 5 pts

Now let's focus on MHC receptors. If you need help identifying which answers you are getting wrong, please email Dr. Y for help.

 

Please select the correct responses for each MHC Class in the table below:

MHC Class IMHC Class II
Expressed (present) on what types of cells?most cellsAPCs and B cells
What type of antigen is displayed by this receptor? (i.e. what kind of antigen does it "show" to other cells?)antigens generated by host cells (endogenous or intracellular antigens)antigens generated outside of host cells (exogenous or extracellular antigenous)
Type of T cell that "sees" or binds to this MHC receptor?Tc cells (Cytotoxic T cells)Th cells (Helper T cells)
Binds which major receptor?TCRTCR
Binds which co-receptor?
CD8CD4

 

Answer 1:
Answer 2:
Answer 3:
Answer 4:
Answer 5:
Answer 6:
Answer 7:
Answer 8:
Answer 9:
Answer 10:
 
Question 11
1 / 1 pts

Suppose a person was born without the ability to produce MHC I molecules. What problem would that create?

 

  
  
  
  
 
Question 12
1 / 1 pts

A patient has just been informed that they have an autoimmune disease that attacks the salivary glands. Autoimmune diseases happen when the body's immune system attacks "self".

 

How would you explain to the patient what is happening inside their body?

  
  
  
  
 
Question 13
1 / 1 pts

A healthy person produces antibodies to pathogens that invade the body. However, if this person becomes infected with HIV and progresses to develop AIDS, the body eventually loses the ability to produce antibodies. Research has shown that the virus attacks and destroys CD4+T cells.

 

Why does destruction of CD4+T cells lead to a loss of antibody synthesis in HIV-infected patients?

  
  
  
  
 
Below are some extra questions relating to innate immunity.
 
Question 14
1 / 1 pts

Upon infection with Influenza A virus, pneumocytes (epithelial cells lining the lungs) start to undergo apoptosis.

 

Which of the following is true about the cells most likely responsible for triggering apoptosis of infected pneumocytes?

  
  
  
  
 
Question 15
1 / 1 pts
After infection from West Nile Virus, astrocytes (in the brain) stop expressing MHC I. Which of the following inflammatory cells is most likely to destroy these infected astrocytes?
  
  
  
  
  
 
Question 16
1 / 1 pts

A virus has just infected a host cell and the host cell initiates a warning/defense response to alert nearby cells. Indicate the correct order of events.

Note: 3 of the events are not relevant or incorrect. Also correctly label those as "Not relevant" to this process.

If you need help identifying what you've matched wrong, please email Dr. Y for your second or third try.

Virus adhesin protein binds to host receptor on the surface of cell.
 
Type 1 Interferons are released and signal in a endocrine fashion to nearby cells.
 
Nearby cells react and destroy cytoplasmic RNAs and lower transcription and translation rates.
 
Extracellular PRRs are activated and send a signal to host nucleus to promote gene expression of stress repsonse genes.
 
Type 1 Interferons are released and signal in a paracrine fashion to nearby cells.
 
Virus releases its genomic RNA into the cell.
 
Viral RNA is recognized and bound by extracellular PRRs.
 
Viral RNA is recognized and bound by intracellular PRRs.
 
Intracellular PRRs are activated and send a signal to host nucleus to promote gene expression of stress repsonse genes.